Transplant Research Innovation — International Network — Data Initiative
Harmonizing clinical, histological, immunological, virological and molecular data from patient populations worldwide — to advance precision medicine in solid organ transplantation.
The TRINITY consortium gathers its principal investigators and partners for a private dinner hosted at the Residence of the Consul General of France, on the occasion of the American Transplant Congress. An evening of Franco-American science, collaboration and friendship — celebrating the people behind the data.
Built on the data-driven methodology of the iBox prognostic system — now an EMA-qualified surrogate endpoint for clinical trials.
Despite advances in immunosuppression, kidney transplant recipients still face significant risks from rejection, viral infection, disease recurrence and graft failure. Early detection and accurate risk stratification remain unmet needs.
Single-center studies, while foundational, cannot account for the heterogeneity in immunological risk, immunosuppressive strategies and clinical practice that exists across transplant populations worldwide. TRINITY was established to close this gap — building a shared, evolving research infrastructure that enables multicenter validation at scale.
More than 50 centers across 20 countries and 4 continents — a combined cohort exceeding 40,000 patients, with data-use agreements and IRB approvals at every site.
Each project operates on the same harmonized datalake, with distinct scientific objectives and data requirements.
A prognostic system for kidney allograft failure, integrating eGFR, proteinuria, histology and immunology. Already validated across seven countries and randomized trials; TRINITY extends it to new centers and populations.
A non-invasive biomarker of graft injury. TRINITY validates the dd-cfDNA model across cohorts and evaluates its association with Banff 2022 microvascular inflammation phenotypes and early post-transplant settings.
One of the largest international BK cohorts in kidney transplantation — integrating viral loads with biopsy findings, dd-cfDNA and outcomes to identify risk factors and build progression-risk tools.
An undercharacterized contributor to graft loss. TRINITY defines the incidence and impact of recurrence across IgA nephropathy, FSGS, membranous and membranoproliferative disease — distinguishing recurrence from rejection.
Data are extracted locally after IRB approval and transferred through secure, end-to-end encrypted protocols.
Local extraction following IRB approval, then secure transfer into the consortium pipeline.
→Cleaning, harmonization and mapping to a common data model of 400+ variables.
→Integration into a centralized, cloud-based repository with end-to-end encryption.
→Real-time querying, visualization and machine-learning pipelines on harmonized data.
Pr. Loupy's research focuses on the development and validation of prognostic models and molecular biomarkers in kidney transplantation. He led the development of the iBox system and the large-scale evaluation of dd-cfDNA for rejection detection.
TRINITY's coordination — data harmonization, quality control and analytical planning — is centrally managed at the Paris Institute for Transplantation & Organ Regeneration. The initiative convenes biannually to review results and define research priorities.
A growing community of academic transplant centers and the people who drive the science forward.
PITOR Institute · Paris
AP-HP · Paris
University of Alberta · Edmonton
CHU Grenobles · Grenoble
CHU Montpellier · Montpellier
CHU Toulouse · Toulouse
Cedars Sinai · Los Angeles
Cleveland Clinic · Cleveland
Hospital Do Rim · Sao Paulo
Duke · Durham
ECMC · Buffalo
Emory University · Atlanta
Foch Hospital · Paris
Georgetown · Washington
Hackensack · New Jersey
Helsinki University Hospital
Intermountain · Salt Lake City
KUMC · Kansas City
MGH · Boston
Medical College of Wisconsin · Milwaukee
Mayo Clinic · Jacksonville
Miami Transplant Institute · Miami
NYU Langone · New York
Necker Hospital • Paris
University of Pennsylvania · Philadelphia
São Paulo Hospital · Sao Paulo
University of Sarajevo · Sarajevo
Sharp Grossmont · La Mesa
Sorbonne (& Tenon & Pitié-Salpêtrière) · Paris
Saint-Louis (& Bichat) · Paris
Tokyo Women's Hospital · Tokyo
Tampa General · Tampa
Tufts Medical Center · Boston
UCLA · Los Angeles
UCSF · San Francisco
USC Hospital · Los Angeles
University of Texas Southwestern · Dallas
University of Wisconsin · Madison
University of Utah · Utah
Virginia Commonwealth University · Richmond
Vanderbilt · Nashville
Washington University · Saint-Louis
Yonsei University · Seoul
University of Zagreb · Zagreb
Temple · Philadelphia
Weill Cornell Hospital · New York
Robert-Debré Hospital · Paris
KU Leuven · Leuven
Centers interested in joining, or contributing data to specific projects, are warmly invited to contact the coordinating team. Investigators may also propose new research projects aligned with the consortium's scientific priorities.